Medication & Genetics

We are all unique inside our genome. Our genes contain instructions on how to metabolize drug substances, for example by constructing different enzymes and membrane proteins for this. Differences between individuals can be seen in the structure of these proteins and enzymes – this causes differences in drug metabolism. Here’s how genetics affect medication:  when someone reacts to a drug very strongly in a very small dose, someone else might not have an effect at all with same dosage.

Various prescribed drugs metabolize through liver enzyme CYP2C19. Different variations of CYP2C19 take part in metabolism of for example clopidogrel, a drug that is used to treat and prevent heart and brain stroke. Even one in six patients using clopidogrel have genetic features, that make this drug metabolize poorly and not provide the prevention of a recurring stroke.

The genetic features in drug metabolism can be solved using pharmacogenetic testing. GeneAccount Service’s genetic test increases medication safety and is a way for personalized medicine without dangerous side effects or ineffective treatments caused by unsuitable drugs.

Test results contain dosing recommendations for more than 150 commonly used drugs and offer a great support for your clinician when prescribing drugs.

GeneAccount Service / Genes

GeneAccount Service genetic test interprets  genes with most pharmacogenetical significance. The examined genes include ABCB1, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A5, F2, F5, SLCO1B1 and VKORC1.

 

GeneAccount Service / Medications

GeneAccount Service’s examined genes define more than 150 individual medications personal suitability. These medications include pharmaceuticals for heart and vasculary diseases, pain, mood and birth control. Look below for examples of medications with pharmacogenetic variance which GeneAccount Service genetic test intreprets.

active_ingredient_nametradenames
abacavirAbacavir/Lamivudin Mylan;Abakavir/Lamivudin Mylan Pharma;Kivexa;Triumeq;Trizivir;Ziagen
allopurinolAllonol;Allopurinol Accord;Apurin Sandoz;Zyloric
amifampridine phosphateFirdapse
amitriptylineAmitriptylin Abcur;Klotriptyl;Klotriptyl Mite;Limbitrol;Pertriptyl;Triptyl
aripiprazoleAbilify;Abilify Maintena;Aripiprazole Accord;Aripiprazole Avansor;Aripiprazole Orion;Aripiprazole Ratiopharm;Aripiprazol Krka;Aripiprazol Stada;Lemilvo
articaineDentocaine;Septocaine;Septocaine Forte;Ubistesin;Ubistesin Mild;Ultracain D-Suprarenin
ascorbic acidBurana-C;Cernevit;C-Vimin;Finrexin;Finrexin Neo;Ibumax-C;Moviprep;Nitrofur-C;Pamolhot-C;Paracetamol+C Ratiopharm;Plenvu;Renavit Renacare;Soluvit;Viant
atazanavirAtazanavir Accord;Atazanavir Krka;Atazanavir Stada
atomoxetineAtomoxetine Accord;Atomoxetine Stada;Atomoxetin Orion;Strattera
atorvastatinAtorbir;Atorvastatin Accord;Atorvastatin Krka;Atorvastatin Orion;Atorvastatin Pfizer;Atorvastatin Ratiopharm;Euvascor;Lipistad;Lipitor;Orbeos;Triveram
azathioprineAzamun;Imurel
brexpiprazoleRxulti
brivaracetamBriviact
bupropionBupropion Orion;Bupropion Sandoz;Mysimba;Voxra;Zyban
caffeineFinrexin;Finrexin Neo;Gencebok;Malvitona;Panadol Coffein;Paramax Comp;Peyona;Treo
capecitabineCapecitabine Accord;Capecitabine Orion;Ecansya;Xeloda
carbamazepineCarbamazepine Essential Pharma;Neurotol Slow;Tegretol;Tegretol Retard
carvedilolCardiol;Carvedilol Hexal;Carvedilol Orion;Carvedilol Stada;Carveratio
celecoxibCelebra;Celecoxib Krka;Celecoxib Orion;Celecoxib Pfizer;Celecoxib Stada
ciprofloxacinCiprofloxacin Fresenius Kabi;Ciprofloxacin Krka;Ciprofloxacin Orion;Ciprofloxacin Ratiopharm;Ciproxin
cisplatinCisplatin Accord
citalopramCitalopram Orion;Citalopram-Ratiopharm;Citalopram Vitabalans;Sepram
clobazamFrisium
clomipramineAnafranil;Anafranil Retard
clopidogrelClopidogrel Actavis;Clopidogrel Krka;Clopidogrel Mylan;Clopidogrel Orion;Clopidogrel Stada;Clopidogrel Taw Pharma;Plavix
clozapineClozapine Accord;Froidir;Leponex
codeineAltermol;Ardinex;Codesan Comp;Katapekt;Mustanparran Yskäntipat Df 2004;Panacod;Paramax-Cod;Professorin Perinteinen Yskänlääke;Recipect
cyclophosphamideSendoxan
dabrafenibTafinlar
dapsoneDapson Scanpharm;Dapson Tillomed
darifenacinEmselex
dextromethorphanResilar;Rometor Ratiopharm;Sir. Ephedrin;Sir. Ephedrin Paediatr.
diazepamDiapam;Medipam;Stesolid
diclofenacArthrotec;Arthrotec Forte;Diclomex;Diclomex Rapid;Dicuno;Motifene Dual;Voltaren;Voltaren Rapid;Voltaren Retard
digoxinDigoxin;Digoxin Orion;Digoxin Orion Mite;Digoxin Orion Semi
dolutegravirTivicay;Triumeq
donepezilAricept;Donepezil Krka;Donepezil Orion;Zauton
doxepinDoxal
duloxetineCymbalta;Duloxetine Accord;Duloxetine Krka;Duloxetine Mylan;Duloxetine Orion;Duloxetine Ratiopharm;Duloxetin Stada;Loxentia;Yentreve
efavirenzAtripla;Efavirenz Aurobindo;Efavirenz Sandoz;Emtenef
eliglustatCerdelga
eltrombopagRevolade
erlotinibErlotinib Avansor;Erlotinib Krka;Erlotinib Orion;Erlotinib Stada;Tarceva
escitalopramCipralex;Escitalopram Accord;Escitalopram Actavis;Escitalopram Krka;Escitalopram Orion;Escitalopram Ratiopharm;Escitalopram Sandoz
eslicarbazepineZebinix
esomeprazoleAcidal;Esomeprazol Actavis;Esomeprazol Krka;Esomeprazol Orion;Esomeprazol Ratiopharm;Esomeprazol Sandoz;Nexium;Vimovo
estradiolActivelle;Angeliq;Cliovelle;Divina;Estalis;Estradot;Estring;Estrofem;Evorel Conti;Evorel Sequi;Femoston 1/10;Femoston 2/10;Femoston Conti 0,5/2,5;Femoston Conti 1/5;Indivina;Kliogest;Novofem;Progynova;Qlaira;Sequidot;Trisekvens;Zoely;Zumenon
estriolOvestin
ethinylestradiolCemisiana;Cypretyl;Daisynelle;Daylette;Denise;Diane Nova;Dienorette;Diza;Dizminelle;Evra;Femoden;Gestinyl;Harmonet;Levesia;Linatera;Lumivela;Martam;Marvelon;Meliane;Mercilon;Microgynon;Midiana;Minulet;Nuvaring;Ornibel;Rigevidoncont;Rubira;Stefaminelle;Tasminetta;Vagiprev;Vonamyl;Vreya;Yanulez;Yasmin;Yasminelle;Yaz
fesoterodineToviaz
flecainideFlecainide Orion;Tambocor;Tambocor Retard
flucloxacillinFlucloxacillin Orion
fluorouracilFluorouracil Accord
fluoxetineFluoxetine Vitabalans;Fluoxetin Mylan;Fluoxone;Seromex;Seronil
flupenthixolFluanxol
flurbiprofenStrefen Orange
flutamideProfamid
fluvastatinFluvastatin Mylan;Lescol Depot
fluvoxamineFluvosol
fosphenytoinPro-Epanutin
galantamineGalantamine Actavis;Galantamin Krka;Galantamin Orion;Galantamin Stada;Reminyl
gefitinibGefitinib Accord;Gefitinib Avansor;Gefitinib Mylan;Gefitinib Ratiopharm;Gefitinib Stada;Iressa
glimepirideAmaryl
glyceryl trinitrateDeponit Nt;Nitro;Nitroglycerin Orion;Perlinganit;Transiderm-Nitro
haloperidolSerenase;Serenase Depot
hydroxychloroquineOxiklorin
ibuprofenArdinex;Burana;Burana-C;Burana-Caps;Burana Slow;Dolerin;Ibumax;Ibumax-C;Ibumetin;Ibuprofen B. Braun;Ibusal;Ibutabs;Ibuver;Ibuxin;Ibuxin Rapid;Pedea
indacaterolOnbrez Breezhaler;Ultibro Breezhaler
irinotecanIrinotecan Accord;Irinotecan Medac;Onivyde Pegylated Liposomal
isoniazidTubilysin
lacosamideVimpat
lansoprazoleGasterix;Helipak A;Helipak K;Lansoprazol Krka;Lanvone;Zolt
levofloxacinLevofloxacin Fresenius Kabi;Levofloxacin Krka;Levofloxacin Orion;Tavanic
lidocaineDepo-Medrol Cum Lidocain;Emla;Lentocilin S 1200;Lidocain;Lidocain C. Adrenalin;Lidocaine Accord;Lidocaine Baxter;Lidocard;Lidokaiinihydrokloridi Kurlausvesi;Lidokain Mylan;Mydrane;Neoproct;Neoproct Yhdistelmäpakkaus;Tapin;Tardocillin 1200;Xylocain Dental Adrenalin
lorazepamLoratsepaami;Lorazepam Macure;Lorazepam Orion;Temesta
losartanCozaar;Cozaar Comp;Cozaar Comp Forte;Losanova;Losarstad;Losarstad Comp;Losartan/Hydrochlorothiazide Krka;Losartan/Hydrochlorothiazide Orion;Losartan/Hydrochlorothiazide Sandoz;Losartan Krka;Losartan Medical Valley;Losartan Orion;Losatrix;Losatrix Comp
lovastatinLovastatin Ratiopharm;Lovastatin Stada
meclizinePostafen
meloxicamMeloxicam Orion;Meloxicam Ratiopharm;Mobic
mepivacaineScandonest
mercaptopurineMercaptopurin Orion;Xaluprine
methadoneDolmed;Metadon Abcur;Metadon Nordic Drugs;Methadone Martindale Pharma
methotrexateEbetrex;Injexate;Methotrexat Accord;Methotrexat Ebewe;Methotrexate Pfizer;Metoject;Metoject Pen;Nordimet;Trexan
methylthioniniumMethylthioninium Chloride Proveblue
metoclopramideMetoclopramide Accord;Metoclopramide Orion;Primperan
metoprololLogimax;Logimax Forte;Metohexal;Metomylan;Metopocor;Metoprolin;Metoprolol Krka;Metoprolol Orion;Metoprolol Ratiopharm;Selocomp Zoc;Seloken;Seloken Zoc;Spesicor Dos
mirabegronBetmiga
mirtazapineMirtazapin Actavis;Mirtazapin Krka;Mirtazapin Orion;Mirtazapin Ratiopharm
mivacuriumMivacron
moclobemideAurorix;Moclobemid Ratiopharm
modafinilModafinil Orion
moxifloxacinAvelox;Moxifloxacin Fresenius Kabi;Moxifloxacin Krka;Moxifloxacin Orion;Moxifloxacin Sanoswiss;Moxifloxacin Stada
mycophenolateCellcept;Mycophenolate Mofetil Accord;Mycophenolate Mofetil Sandoz;Myfenax;Myfortic
nebivololHypoloc;Hypoloc Comp;Nebivolol Orion
nevirapineNevirapine Accord;Nevirapine Mylan;Viramune
nilotinibTasigna
nitrofurantoinFurantoina;Nitrofur-C
nortriptylineNoritren
olanzapineOlanzapine Accord;Olanzapine Mylan;Olanzapin Orion;Olanzapin Ratiopharm;Olanzapin Sandoz;Zalasta;Zypadhera;Zyprexa;Zyprexa Velotab
omeprazoleLosec;Losec Mups;Omeprazol Actavis;Omeprazol Ratiopharm;Omestad
ondansetronOndansetron Accord;Ondansetron Bluefish;Ondansetron Fresenius Kabi;Ondansetron Hameln;Ondansetron Stada;Zofran;Zofran Zydis
oxaliplatinOxaliplatin Accord
oxazepamOpamox;Oxamin
oxcarbazepineApydan;Oxcarbazepin Orion;Trileptal
oxycodoneOxanest;Oxycodone/Naloxone Ratiopharm;Oxycodone Orion;Oxycodone Ratiopharm;Oxycodone Stada;Oxycodone Vitabalans;Oxycontin;Oxynorm;Oxyratio;Oxyratio Depot;Tanonalla;Targiniq
paliperidoneTrevicta;Xeplion
palonosetronAkynzeo;Aloxi;Palonosetron Accord;Palonosetron Macure;Palonosetron Reig Jofre;Palonosetron Stada
pantoprazolePantopratsoli Sun;Pantoprazol Actavis;Pantoprazole Ratiopharm;Pantoprazol Krka;Pantoprazol Mylan;Pantoprazol Orion;Somac;Somac Control
paroxetineOptipar;Paroxetin Orion;Seroxat
pazopanibVotrient
peginterferon alfa-2aPegasys
perphenazinePeratsin;Peratsin Dekanoaatti;Pertriptyl
phenytoinHydantin
pioglitazoneIncresync;Pioglitazone Accord;Pioglitazone Actavis
prasugrelEfient
pravastatinPravastatin Orion;Pravastatin Ratiopharm;Pravastatin Sandoz
prilocaineCitanest Dental Octapressin;Emla;Takipril;Tapin
propranololDociton Retard;Hemangiol;Propral;Propranolol Accord;Ranoprin
rabeprazolePariet;Rabeprazol Krka
raltegravirIsentress
rasburicaseFasturtec
ribavirinRebetol
risperidoneRismyl;Risperdal;Risperdal Consta;Risperidone Stada;Risperidon Krka;Risperidon Orion;Risperidon Ratiopharm;Risperidon Sandoz
rocuroniumEsmeron;Rocuronium B. Braun;Rocuronium Fresenius Kabi
romiplostimNplate
ropivacaineRopivacaine Bioq;Ropivacain Fresenius Kabi
rosuvastatinCrestor;Rosuvastatin Accord;Rosuvastatin Actavis;Rosuvastatin/Ezetimibe Ratiopharm;Rosuvastatin Krka;Rosuvastatin Mylan;Rosuvastatin Orion;Rosuvastatin Ratiopharm;Rosuvastatin Sandoz;Rosuvastatin Stada;Rosuvastatin Xiromed
sertindoleSerdolect
sertralineSertraline Accord;Sertralin Hexal;Sertralin Krka;Sertralin Orion;Sertralin Ratiopharm;Zoloft
simvastatinLipcut;Simvastatin Actavis;Simvastatin Krka;Simvastatin Orion;Simvastatin Ratiopharm;Zocor
siponimodMayzent
sofosbuvirEpclusa;Harvoni;Sovaldi;Vosevi
sulfadiazineDitrim Duplo
sulfamethoxazoleCotrim;Cotrim Forte
sulfasalazineSalazopyrin;Salazopyrin En
suxamethoniumSukolin;Suxamethonium Ethypharm
tacrolimusAdport;Advagraf;Dailiport;Envarsus;Modigraf;Prograf
tamoxifenTadex;Tamofen
tamsulosinDuodart;Dutasteride/Tamsulosinhydrochlorid Accord;Dutasteride/Tamsulosinhydrochloride Mylan;Dutasteride/Tamsulosinhydrochloride Sandoz;Dutasteride/Tamsulosinhydrochlorid Glenmark;Dutasteride/Tamsulosinhydrochlorid Medical Valley;Dutasteride/Tamsulosinhydrochlorid Ratiopharm;Dutasteride/Tamsulosinhydrochlorid Stada;Dutasteride/Tamsulosin Orion;Expros;Omnic;Omnic Ocas;Promictan;Tamictor;Tamsact;Tamsulosiinihydrokloridi Orion;Tamsumin;Urizia
tegafurTeysuno
terbinafineFungorin;Terbinafin Hexal;Terbinafin Ratiopharm
tetrabenazineDystardis;Tetmodis
tiboloneLivial;Tibelia;Tibocina;Tibolon Orifarm
ticagrelorBrilique
tolterodineDetrusitol;Detrusitol Sr;Tolterodin Actavis;Tolterodine Sandoz;Tolterodin Pfizer;Tolterodin Ratiopharm
tramadolDolatramyl;Skudexa;Tradolan Retard;Tramadin;Tramadol Hexal;Tramadol Krka;Tramadol/Paracetamol Krka;Tramadol Retard Hexal;Tramadol Retard Sandoz;Tramadol Vitabalans;Tramal;Tramal Retard;Tramium;Trampalgin
trimipramineSurmontil
valproic acidAbsenor;Deprakine;Orfiril;Orfiril Long;Valproat Life Medical;Valproat Sandoz
venlafaxineEfexor Depot;Venlafaxin Krka;Venlafaxin Orion;Venlafaxin Ratiopharm
vincristineOncovin
voriconazoleVfend;Voriconazole Accord;Voriconazole Fresenius Kabi;Voriconazole Sandoz
vortioxetineBrintellix
warfarinMarevan;Marevan Forte
zuclopenthixolCisordinol;Cisordinol-Acutard;Cisordinol Depot